@misc{painter2026dia,
author = {Painter, Jeffery},
title = {Leveraging Semantic Clinical Similarity to Improve Early Signal Detection: Ontology-Informed Bayesian Borrowing for Pharmacovigilance Signal Detection},
howpublished = {Presentation in the session ``Utilizing Signal Detection Methodologies: A Toolkit for Diverse Product Types,'' DIA 2026 Global Annual Meeting},
year = {2026},
month = jun,
day = {17},
note = {Session #643, 4:00--5:00 PM, Room 118AB}
}
@article{matthewman2026large,
title={Large language models and retrieval augmented generation for complex clinical codelists: evaluating performance and assessing failure modes},
author={Matthewman, Julian and Denaxas, Spiros and Langan, Sinead and Painter Jr, Jeffery L and Bate, Andrew},
journal={medRxiv},
pages={2026--04},
year={2026},
publisher={Cold Spring Harbor Laboratory Press},
doi = {10.64898/2026.04.23.26351098}
}
@article{kefala2026development,
title={Development of a European Union Time-Indexed Reference Dataset for Assessing the Performance of Signal Detection Methods in Pharmacovigilance using a Large Language Model},
author={Kefala, Maria and Painter, Jeffery L and Bukhari, Syed Tauhid and Sessa, Maurizio},
journal={arXiv preprint arXiv:2603.26544},
year={2026},
doi = {10.48550/arXiv.2603.26544}
}
@misc{painter2026ctgdb,
title = {{CTG-DB: An Ontology-Based Transformation of ClinicalTrials.gov to Enable Cross-Trial Drug Safety Analyses}},
author = {Painter, J.L. and Haguinet, F. and Bate, A.},
year = 2026,
month = 3,
doi = {10.48550/arXiv.2603.15936},
}
2026
5.
Orchestrating generative AI in pharmacovigilance: predicting and preempting the unpredictable Ramcharran, Darmendra, Painter, Jeffery L, Kara, Vijay, Glaser, Michael, Vanini, Marco, Chalamalasetti, Venkateswara Rao, Golds, Christopher, Abdelkarim, Azza, Bate, Andrew, and Stegmann, Jens-Ulrich. Orchestrating generative AI in pharmacovigilance: predicting and preempting the unpredictable. Therapeutic Advances in Drug Safety, 2025.
@article{ramcharran2025orchestrating,
title = {{Orchestrating generative AI in pharmacovigilance: predicting and preempting the unpredictable}},
author = {Ramcharran, Darmendra and Painter, Jeffery L and Kara, Vijay and Glaser, Michael and Vanini, Marco and Chalamalasetti, Venkateswara Rao and Golds, Christopher and Abdelkarim, Azza and Bate, Andrew and Stegmann, Jens-Ulrich},
year = 2025,
journal = {Therapeutic Advances in Drug Safety},
publisher = {SAGE Publications Sage UK: London, England},
volume = 16,
pages = 20420986251396023,
doi = {10.1177/20420986251396023}
}
@article{hakim2025need,
title = {{The need for guardrails with large language models in pharmacovigilance and other medical safety critical settings}},
author = {Hakim, Joe B and Painter, Jeffery L and Ramcharran, Darmendra and Kara, Vijay and Powell, Greg and Sobczak, Paulina and Sato, Chiho and Bate, Andrew and Beam, Andrew},
year = 2025,
journal = {Scientific Reports},
publisher = {Nature Publishing Group UK London},
volume = 15,
number = 1,
pages = 27886
}
@article{painter2025cdm,
title = {{Perspective review: Will generative AI make common data models obsolete in future analyses of distributed data networks?}},
author = {Jeffery L. Painter and Darmendra Ramcharran and Andrew Bate},
year = 2025,
journal = {Therapeutic Advances in Drug Safety},
volume = 16,
number = {},
pages = 20420986251332743,
doi = {10.1177/20420986251332743}
}
@misc{haguinet2025bdb,
title = {{Semantic Similarity-Informed Bayesian Borrowing for Quantitative Signal Detection of Adverse Events}},
author = {Haguinet, F. and Painter, J.L. and Powell, G.E. and Callegaro, A and Bate, A.},
year = 2025,
month = {03},
doi = {10.48550/arXiv.2504.12052},
note = {Posted 2025 Apr 16},
howpublished = {arXiv preprint arXiv:2504.12052}
}
@misc{painter2025ssm,
title = {{Ontology-based Semantic Similarity Measures for Clustering Medical Concepts in Drug Safety}},
author = {Painter, J.L. and Haguinet, F. and Powell, G.E. and Bate, A.},
year = 2025,
month = 11,
doi = {10.48550/arXiv.2503.20737},
note = {Presented November 16, 2025},
howpublished = {AMIA Annual Symposium}
}
@article{painter2025automating,
title = {{Automating pharmacovigilance evidence generation: using large language models to produce context-aware structured query language}},
author = {Painter, Jeffery L and Chalamalasetti, Venkateswara Rao and Kassekert, Raymond and Bate, Andrew},
year = 2025,
journal = {JAMIA open},
publisher = {Oxford University Press},
volume = 8,
number = 1,
pages = {ooaf003}
}
@inproceedings{haguinet2024application,
title = {{An Application of Bayesian Modelling for Information Sharing in Safety Signal Detection}},
author = {Haguinet, F and Mahaux O and Painter, J.L. and Bate, A.},
year = 2024,
booktitle = {2024 ISPE Annual Meeting, Berlin, Germany},
volume = 33,
pages = {601--602}
}
@inproceedings{haguinet2024ontology,
title = {{Ontology-based Semantic Similarity Measures in Drug Safety: A Literature Review}},
author = {Haguinet, F and Painter, J.L. and Bate, A.},
year = 2024,
booktitle = {2024 ISPE Annual Meeting, Berlin, Germany},
volume = 33,
pages = {601--602}
}
@misc{painter2024rshiny,
title = {{Developing an R Shiny Interactive Module for Teaching Statistics to High School Students}},
author = {Painter, Jeffery},
year = 2024,
month = {07},
pages = {},
doi = {10.13140/RG.2.2.28736.96005}
}
@article{hakim2024need,
title = {{The Need for Guardrails with Large Language Models in Medical Safety-Critical Settings: An Artificial Intelligence Application in the Pharmacovigilance Ecosystem}},
author = {Hakim, Joe B and Painter, Jeffery L and Ramcharran, Darmendra and Kara, Vijay and Powell, Greg and Sobczak, Paulina and Sato, Chiho and Bate, Andrew and Beam, Andrew},
year = 2024,
journal = {arXiv preprint arXiv:2407.18322}
}
@article{minikel2024refining,
title = {{Refining the impact of genetic evidence on clinical success}},
author = {Minikel, Eric Vallabh and Painter, Jeffery L and Dong, Coco Chengliang and Nelson, Matthew R},
year = 2024,
journal = {Nature},
publisher = {Nature Publishing Group UK London},
volume = 629,
number = 8012,
pages = {624--629}
}
@inproceedings{painter2023enhancing,
title = {{Enhancing drug safety documentation search capabilities with large language models: a user-centric approach}},
author = {Painter, Jeffery L and Mahaux, Olivia and Vanini, Marco and Kara, Vijay and Roshan, Christie and Karwowski, Marcin and Chalamalasetti, Venkateswara Rao and Bate, Andrew},
year = 2023,
booktitle = {2023 International Conference on Computational Science and Computational Intelligence (CSCI)},
pages = {49--56},
organization = {IEEE}
}
@article{talekar2023semi,
title = {{Semi-automation of keratopathy visual acuity grading of corneal events in belantamab mafodotin clinical trials: clinical decision support software}},
author = {Talekar, Mala K and Painter, Jeffery L and Elizalde, Mica A and Thomas, Michele and Stein, Heather K},
year = 2023,
journal = {Frontiers in Digital Health},
publisher = {Frontiers Media SA},
volume = 5,
pages = 1138453
}
@article{painter2023industry,
title = {{An industry perspective on the use of machine learning in drug and vaccine safety}},
author = {Painter, Jeffery L and Kassekert, Raymond and Bate, Andrew},
year = 2023,
journal = {Frontiers in Drug Safety and Regulation},
publisher = {Frontiers Media SA},
volume = 3,
pages = 1110498
}
@inproceedings{painter2022leveraging,
title = {{Leveraging Data Pathways for Next Generation Safety Monitoring of Medicines and Vaccines}},
author = {Painter, Jeffery L and Girard, Laurie and Glaser, Michael and Bate, Andrew},
year = 2022,
booktitle = {2022 International Conference on Computational Science and Computational Intelligence (CSCI)},
pages = {1570--1576},
organization = {IEEE}
}
@article{pimenta2022identifying,
title = {{Identifying barriers to enrollment in patient pregnancy registries: building evidence through crowdsourcing}},
author = {Pimenta, Jeanne M and Painter, Jeffery L and Gemzoe, Kim and Levy, Roger Abramino and Powell, Marcy and Meizlik, Paige and Powell, Gregory},
year = 2022,
journal = {JMIR Formative Research},
publisher = {JMIR Publications Inc., Toronto, Canada},
volume = 6,
number = 5,
pages = {e30573}
}
@article{powell2022engaging,
title = {{Engaging patients via online healthcare fora: three pharmacovigilance use cases}},
author = {Powell, Greg and Kara, Vijay and Painter, Jeffery L and Schifano, Lorrie and Merico, Erin and Bate, Andrew},
year = 2022,
journal = {Frontiers in Pharmacology},
publisher = {Frontiers Media SA},
volume = 13,
pages = 901355
}
2022
24.
Artificial Intelligence Based on Machine Learning in Pharmacovigilance: A Scoping Review Kompa, Benjamin, Hakim, Joe B, Palepu, Anil, Kompa, Kathryn Grace, Smith, Michael, Bain, Paul A, Woloszynek, Stephen, Painter, Jeffery L, Bate, Andrew, and Beam, Andrew L. Artificial intelligence based on machine learning in pharmacovigilance: a scoping review. Drug Safety, 2022.
@article{kompa2022artificial,
title = {{Artificial intelligence based on machine learning in pharmacovigilance: a scoping review}},
author = {Kompa, Benjamin and Hakim, Joe B and Palepu, Anil and Kompa, Kathryn Grace and Smith, Michael and Bain, Paul A and Woloszynek, Stephen and Painter, Jeffery L and Bate, Andrew and Beam, Andrew L},
year = 2022,
journal = {Drug Safety},
publisher = {Springer},
volume = 45,
number = 5,
pages = {477--491}
}
@inproceedings{powell2020longitudinal,
title = {{Longitudinal medical insights from internet fora}},
author = {Powell, Gregory and Painter, Jeffery L and Jay, Jessica and Yin, Shengmei and Bate, Andrew},
year = 2020,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 29,
pages = {509--510},
doi = {https://doi.org/10.1002/pds.5114},
organization = {WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}
}
@article{gartland2021developing,
title = {{Developing crowdsourced training data sets for pharmacovigilance intelligent automation}},
author = {Gartland, Alex and Bate, Andrew and Painter, Jeffery L and Casperson, Tim A and Powell, Gregory Eugene},
year = 2021,
journal = {Drug Safety},
publisher = {Springer},
volume = 44,
pages = {373--382}
}
@inproceedings{gemzoe2019crowdsourcing,
title = {{Crowdsourcing as a novel method to assess the impact of drug exposure on Belimumab pregnancy registry enrollment}},
author = {Gemzoe, Kim and Painter, Jeffery L and Pimenta, Jeanne and Powell, Greg},
year = 2019,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 28,
pages = {436--436},
organization = {WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}
}
Using Social Listening Data to Monitor Misuse and Nonmedical
Use of Bupropion: A Content Analysis Anderson, Laurie S, Bell, Heidi G, Gilbert, Michael, Davidson, Julie E, Winter, Christina, Barratt, Monica J, Win, Beta, Painter, Jeffery L, Menone, Christopher, Sayegh, Jonathan, and others. Using social listening data to monitor misuse and nonmedical use of bupropion: a content analysis. JMIR Public Health and Surveillance, 2017.
@article{anderson2017using,
title = {{Using social listening data to monitor misuse and nonmedical use of bupropion: a content analysis}},
author = {Anderson, Laurie S and Bell, Heidi G and Gilbert, Michael and Davidson, Julie E and Winter, Christina and Barratt, Monica J and Win, Beta and Painter, Jeffery L and Menone, Christopher and Sayegh, Jonathan and others},
year = 2017,
journal = {JMIR Public Health and Surveillance},
publisher = {JMIR Publications Inc., Toronto, Canada},
volume = 3,
number = 1,
pages = {e6174}
}
@inproceedings{casperson2016strategies,
title = {{Strategies for distributed curation of social media data for safety and pharmacovigilance}},
author = {Casperson, Tim A and Painter, Jeffery L and Dietrich, Juergen},
year = 2016,
booktitle = {Proceedings of the International Conference on Data Science (ICDATA)},
pages = 118,
organization = {The Steering Committee of The World Congress in Computer Science, Computer~…}
}
2016
36.
Social Media Listening for Routine Post-Marketing Safety Surveillance Powell, Gregory E, Seifert, Harry A, Reblin, Tjark, Burstein, Phil J, Blowers, James, Menius, J Alan, Painter, Jeffery L, Thomas, Michele, Pierce, Carrie E, Rodriguez, Harold W, and others. Social media listening for routine post-marketing safety surveillance. Drug safety, 2016.
@article{powell2016social,
title = {{Social media listening for routine post-marketing safety surveillance}},
author = {Powell, Gregory E and Seifert, Harry A and Reblin, Tjark and Burstein, Phil J and Blowers, James and Menius, J Alan and Painter, Jeffery L and Thomas, Michele and Pierce, Carrie E and Rodriguez, Harold W and others},
year = 2016,
journal = {Drug safety},
publisher = {Springer},
volume = 39,
pages = {443--454}
}
2016
37.
Performance of Stratified and Subgrouped Disproportionality Analyses in Spontaneous Databases Seabroke, Suzie, Candore, Gianmario, Juhlin, Kristina, Quarcoo, Naashika, Wisniewski, Antoni, Arani, Ramin, Painter, Jeffery, Tregunno, Philip, Noren, G Niklas, and Slattery, Jim. Performance of stratified and subgrouped disproportionality analyses in spontaneous databases. Drug safety, 2016.
@article{seabroke2016performance,
title = {{Performance of stratified and subgrouped disproportionality analyses in spontaneous databases}},
author = {Seabroke, Suzie and Candore, Gianmario and Juhlin, Kristina and Quarcoo, Naashika and Wisniewski, Antoni and Arani, Ramin and Painter, Jeffery and Tregunno, Philip and Noren, G Niklas and Slattery, Jim},
year = 2016,
journal = {Drug safety},
publisher = {Springer},
volume = 39,
pages = {355--364}
}
@inproceedings{disantostefano2015safety,
title = {{Safety Assessment and Selection Bias: Who Uses Social Media to Communicate About Medications?}},
author = {DiSantostefano, Rachael L and Painter, Jeffery L and Thomas, Michele and Powell, Greg},
year = 2015,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 24,
pages = {547--548},
organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}
}
@inproceedings{thomas2015social,
title = {{What are People Talking About? Medication Discussions on Social Media}},
author = {Thomas, Michele and Turnbull, Bradley and Painter, Jeffery and DiSantostefano, Rachael and Powell, Greg},
year = 2015,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 24,
pages = {547--548},
organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}
}
2015
40.
Comparison of Events in Spontaneous Adverse Event Reports To Events Discussed Within Context of Drug Use on Facebook and Twitter Powell, Gregory, Bell, Heidi, Rodriguez, Harold, Thomas, Michele, Painter, Jeffery, Harvey, Cath, Blowers, James, and Dasgupta, Nabarun. Comparison of Events in Spontaneous Adverse Event Reports to Events Discussed Within Context of Drug Use on Facebook and Twitter. , 2015.
@inproceedings{powell2015comparison,
title = {{Comparison of Events in Spontaneous Adverse Event Reports to Events Discussed Within Context of Drug Use on Facebook and Twitter}},
author = {Powell, Gregory and Bell, Heidi and Rodriguez, Harold and Thomas, Michele and Painter, Jeffery and Harvey, Cath and Blowers, James and Dasgupta, Nabarun},
year = 2015,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 24,
pages = {441--441},
organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA}
}
2015
41.
The support of human genetic evidence for approved drug indications Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, and others. The support of human genetic evidence for approved drug indications. Nature genetics, 2015.
@article{nelson2015support,
title = {{The support of human genetic evidence for approved drug indications}},
author = {Nelson, Matthew R and Tipney, Hannah and Painter, Jeffery L and Shen, Judong and Nicoletti, Paola and Shen, Yufeng and Floratos, Aris and Sham, Pak Chung and Li, Mulin Jun and Wang, Junwen and others},
year = 2015,
journal = {Nature genetics},
publisher = {Nature Publishing Group US New York},
volume = 47,
number = 8,
pages = {856--860}
}
@article{parks2013proposed,
title = {{A proposed modification to Hy's law and Edish criteria in oncology clinical trials using aggregated historical data}},
author = {Parks, Daniel and Lin, Xiwu and Painter, Jeffery L and Cheng, Jie and Hunt, Christine M and Spraggs, Colin F and Nelson, Jeanenne J and Curtis, Lloyd and Menius, J Alan and Lee, Kwan R},
year = 2013,
journal = {Pharmacoepidemiology and drug safety},
publisher = {Wiley Online Library},
volume = 22,
number = 6,
pages = {571--578}
}
@article{cheng2012predicting,
title = {{Predicting breast cancer chemotherapeutic response using a novel tool for microarray data analysis}},
author = {Cheng, Jie and Greshock, Joel and Painter, Jeffery and Lin, Xiwu and Lee, Kwan and Zheng, Shu and Menius, Alan},
year = 2012,
journal = {Journal of integrative bioinformatics},
publisher = {De Gruyter},
volume = 9,
number = 2,
pages = {80--87}
}
2012
44.
Performance of Observational Screening by System Organ Class Powell, Gregory E and Painter, Jeffery L. Performance of observational screening by system organ class. , 2012.
@inproceedings{powell2012performance,
title = {{Performance of observational screening by system organ class}},
author = {Powell, Gregory E and Painter, Jeffery L},
year = 2012,
booktitle = {PHARMACOEPIDEMIOLOGY AND DRUG SAFETY},
volume = 21,
pages = {231--231},
organization = {WILEY PERIODICALS, INC ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA~…}
}
@article{lin2012validation,
title = {{Validation of multivariate outlier detection analyses used to identify potential drug-induced liver injury in clinical trial populations}},
author = {Lin, Xiwu and Parks, Daniel and Painter, Jeffery and Hunt, Christine M and Stirnadel-Farrant, Heide A and Cheng, Jie and Menius, Alan and Lee, Kwan},
year = 2012,
journal = {Drug safety},
publisher = {Springer},
volume = 35,
pages = {865--875}
}
@inproceedings{painter2012imaging,
title = {{An Imaging Framework for the Analysis of Longitudinal High-Dimensional Data}},
author = {Painter, Jeffery L},
year = 2012,
booktitle = {Proceedings of the International Conference on Image Processing, Computer Vision, and Pattern Recognition (IPCV)},
pages = 1,
organization = {The Steering Committee of The World Congress in Computer Science, Computer~…}
}
@inproceedings{painter2011enhanced,
author = {Painter, Jeffery L.},
title = {Enhanced Biomedical Taxonomy Mapping Through Use of a Semantic Measure of Proximity},
booktitle = {Proceedings of the 2011 International Conference on Information \& Knowledge Engineering (IKE 2011)},
editor = {Arabnia, Hamid R. and Hashemi, Ray R.},
pages = {187--191},
year = {2011},
address = {Las Vegas, NV, USA},
publisher = {CSREA Press},
isbn = {1-60132-188-0},
note = {WorldComp 2011, July 18--21, 2011}
}
@article{reisinger2010development,
title = {{Development and evaluation of a common data model enabling active drug safety surveillance using disparate healthcare databases}},
author = {Reisinger, Stephanie J and Ryan, Patrick B and O'Hara, Donald J and Powell, Gregory E and Painter, Jeffery L and Pattishall, Edward N and Morris, Jonathan A},
year = 2010,
journal = {Journal of the American Medical Informatics Association},
publisher = {BMJ Group BMA House, Tavistock Square, London, WC1H 9JR},
volume = 17,
number = 6,
pages = {652--662}
}
@inproceedings{painter2010containing,
author = {Painter, Jeffery L.},
title = {Containing the Cloud: Security Issues in a Large-Scale Observational Pharmacovigilance Research Project},
booktitle = {Proceedings of the 2010 International Conference on Security \& Management (SAM 2010)},
editor = {Arabnia, Hamid R. and Daimi, Kevin and Grimaila, Michael R. and Markowsky, George},
pages = {3--9},
year = {2010},
address = {Las Vegas, NV, USA},
publisher = {CSREA Press},
isbn = {1-60132-159-7},
note = {WorldComp 2010, July 12--15, 2010}
}
@inproceedings{painter2010toward,
title = {{Toward automating an inference model on unstructured terminologies: OXMIS case study}},
author = {Painter, Jeffery L},
year = 2010,
booktitle = {Advances in Computational Biology},
pages = {645--651},
organization = {Springer}
}
@inproceedings{painter2009codeslinger,
title = {{Codeslinger: An interactive biomedical ontology browser}},
author = {Painter, Jeffery L and Flowers, Natalie L},
year = 2009,
booktitle = {Conference on Artificial Intelligence in Medicine in Europe},
pages = {260--264},
organization = {Springer}
}
@article{merrill2008construction,
title = {{Construction and annotation of a UMLS/SNOMED-based drug ontology for observational pharmacovigilance}},
author = {Merrill, Gary H and Ryan, Patrick B and Painter, Jeffery L},
year = 2008,
journal = {Methods},
publisher = {Citeseer}
}
@inproceedings{ryan2008defining,
title = {{Defining medical conditions by mapping ICD-9 to MedDRA: a systematic approach to integrating disparate observational data sources for enabling enhanced pharmacovigilance analyses}},
author = {Ryan, PB and Painter, JL and Merrill, GH},
year = 2008,
booktitle = {Poster presented at the 44th Annual Drug Information Association Meeting, Boston, MA}
}
@article{merrill2008using,
title = {{Using SNOMED to normalize and aggregate drug references in the Safetyworks observational pharmacovigilance project}},
author = {Merrill, Gary H and Ryan, Patrick B and Painter, Jeffery L},
year = 2008,
journal = {KR-MED 2008},
pages = 126
}
Introduction to the UMLS for Text Analytics JL Painter and GH Merrill. Technical Briefing for NC State Univeristy's Advanced Analytics Graduate Program. Presented September 12, 2007.
@inproceedings{painter2006inter,
title = {{Inter-translation of Biomedical Coding Schemes Using UMLS.}},
author = {Painter, Jeffrey L and Kleiner, Kristopher M and Merrill, Gary H},
year = 2006,
booktitle = {AAAI Fall Symposium: Semantic Web for Collaborative Knowledge Acquisition},
pages = {110--111}
}
